TLR4/PKCα/occludin signaling pathway may be related to blood‑brain barrier damage

Carbon metabolism of Beauveria bassiana may be related to virulence against Plutella xylostella and Leptinotarsa decemlineata

Angiopoietin-like protein 8 (betatrophin) may inhibit hepatocellular carcinoma through suppressing of the Wnt signaling pathway

Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β-catenin pathway. We aimed to evaluate the effects of recombinant ANGPTL8 on Wnt/β-catenin signaling in human liver carcinom...

Strong, low-barrier hydrogen bonds may be available to enzymes.

The debate over the possible role of strong, low-barrier hydrogen bonds in stabilizing reaction intermediates at enzyme active sites has taken place in the absence of an awareness of the upper limits to the strengths of low-barrier hydrogen bonds involving amino acid side chains. Hydrogen bonds exhibit their maximal strengths in isolation, i.e., in the gas phase. In this work, we measured the i...

Antitrust law may be a barrier to collaboration.

Other countries favor more regulatory strategies, such as all-payer rate setting for hospitals and physicians in Germany, and single-payer systems in France and Canada. New data show that the United States continues to spend far more than its Western allies on healthcare—and with lcss-than-universal coverage (George J. Schicber, Jean-Pierre Poullier, and Leslie M. Grccnwald, "Health Spending, D...

Different Cytotoxic Effects of Caper from Different Geographical Regions May Be Related to Changes in Mitochondrial Sirt3

Background and objectives: Beside its nutritional role, caper (Capparis spinosa) has long been used as an analgesic, anti-inflammatory, anti-diabetic and anti-cancer remedy. In the present study, we tested whether this plant can make effective changes in Sirt3 and mitochondrial function in colorectal carcinoma cell line since mitochondrial dysfunction has long been imp...